Insulin Signalling, Action and Secretion

The pancreas recognises a constant rise in blood glucose concentration after carbs are consumed, digested, and absorbed, and produces insulin to drive an increase in glucose level in the bloodstream, a condition known as hyperglycemia. Type 1 diabetes is caused by a significant decrease in insulin production due to beta cell death caused by autoimmunity. Type-2 diabetes is a complex condition characterised by a progressive increase in insulin resistance and a lack of insulin production, resulting in overt hyperglycemia.

 

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