Insulin Signalling, Action and Secretion

Insulin signalling occurs when carbohydrates are consumed, digested, and absorbed, the pancreas senses the constant rise in blood glucose concentration and releases insulin to promote an increase of glucose level from the blood stream which is characterized by hyperglycemia. Lack of severe reduction in insulin secretion due to auto immune destruction of beta cells is the cause for type 1 diabetes. The advancement of type 2 diabetes is complex, which involves dynamic increase of insulin resistance and relative deficiency in insulin secretion, leading to overt hyperglycemia.

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