Serge Bottari, obtained his M.D. and his Ph.D. (Biochemistry) degrees at the Free University Brussels, Belgium. He specialized in OB/GYN and was a Post-Doctoral Fellow and Research Associate at UC San Francisco. After having been a project leader at Sandoz and CIBA-Geigy in Basle, Switzerland, he became Professor of Cell Biology at the Medical School and Head of Endocrine Biology at the University Hospital in Grenoble, France, in 1993. While still a medical student, he participated in the first purification of a G-protein coupled receptor by affinity chromatography to be reported in 1977 (Vauquelin G et al. PNAS 74:3710-14). His first publication on structure-activity affinity of ß-adrenergic receptors appeared in 1979. His major contributions have been in the field of adrenergic and angiotensin receptors, in particular the AT2 receptor which he reported as one of the first GPCRs to activate tyrosine phosphatases and to regulate endothelial cell proliferation. He also participated in the development of the angiotensin AT1 receptor antagonist valsartan. He published over 70 articles in premium journals which have been cited more than 4000 times and is member of several editorial boards and expert committees (INSERM, HCERES, HAS, Marie Curie COFUND,…). His current work focuses among others on the molecular mechanisms involved in insulin resistance, infertility, nitro-oxidative stress and on the development of novel diagnostic tools.
